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C. Sussman

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Open access Sep 2026

Evidence for a tubular basement membrane–cilia connection in autosomal dominant polycystic kidney disease pathogenesis

Autosomal dominant polycystic kidney disease (ADPKD), mainly driven by pathogenic variants in PKD1 and PKD2, is the most common inherited cause of kidney failure. Details of ADPKD pathogenesis are incompletely resolved, but primary cilia are an integral component. There is also evidence for changes to the tubular basem...

C. Sussman, P. Harris · 0 citations

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