Formulation Strategies in the Development of Novel Nanostructured Multiparticulate Drug Delivery System for Poorly Water Soluble Antipsychotics: Ziprasidone Hydrochloride Monohydrate and Paliperidone
Poor aqueous solubility remains one of the most persistent barriers to successful oral drug development, particularly for crystalline molecules for which dissolution rather than membrane permeability is the dominant rate-limiting step. Lipid-based systems, nanocrystals and nanosuspensions have therefore become importan...