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Author

C. Van den Haute

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Open access Aug 2026

ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis

Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in astrocytes, governs brain polyamine balance. Using biochemical, cellula...

S. van Veen, Emily Meeus, D. Irala et al. · 1 citation
Open access Aug 2026

Fluorescence-Gated Flow Cytometry Approach for Measuring Lipid Flippase Activity in Mammalian Cells

P4‑ATPase lipid flippases establish transbilayer lipid asymmetry in eukaryotic membranes, with increasing evidence indicating a role for interacting partners in regulating flippase activity. However, assessing interactor‑dependent effects on flippase activity in mammalian cells is complicated by heterogeneous protein e...

Klara T. Scholtissek, C. Van den Haute, F. Pamula et al. · 0 citations

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