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Author

C. von Mering

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Open access Oct 2026

Switches in alternatively spliced isoforms impact protein and drug interactions in melanoma, ovarian cancer, and acute myeloid leukemia.

BACKGROUND Alternative splicing is a cellular process and a primary source of proteome diversity. Switches in the Most Dominant Transcript (MDT), where the predominantly expressed isoform changes between normal and cancer samples, have been implicated in disrupting protein interaction networks and driving tumour progre...

Tülay Karakulak, H. Moch, C. von Mering et al. · 0 citations

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