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C. Xue

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Review Sep 2026

Engineering defensins: Heterologous expression strategies from genetic engineering to synthetic biology.

Defensins are a structurally diverse class of host defense peptides with broad-spectrum antimicrobial and immunomodulatory activities. Their broader applications in biomedicine and biotechnology, however, remain constrained by limited natural availability and difficulties associated with heterologous production, includ...

Jun-Hao Guo, Min-Na Qiu, You-Xin Meng et al. · 0 citations
Review Open access Jul 2026

Metabolic engineering of Komagataella phaffii for enhanced production of heterologous proteins and small molecules: key strategies and future directions

This review provides an overview of advances in K. phaffii metabolic engineering and analyzes core optimization strategies, including metabolic flux control, metabolic dynamic control, application of system modeling, chassis cell optimization, and recombinant protein and small-molecule production.

Jiao-Yu Xin, Lu Zhao, You-Xin Meng et al. · 1 citation

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