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Open access Oct 2026

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

These findings position SPP1 + macrophages as central drivers of NAC resistance in CRLM and highlight the spatial immune barrier they create as a promising therapeutic target for overcoming chemoresistance and improving immunotherapy responses.

Jing-Zhi Tang, Wei-Jie Hao, Xi-Gan He et al. · 0 citations
Aug 2026

Ultrasound-Based IHC4-Associated Radiomic Model for Predicting Late Recurrence in ER-Positive Breast Cancer: A Multicenter Retrospective Study.

The IHC4-associated radiomic model may serve as a noninvasive biomarker for predicting prognosis in ER-positive breast cancer and to support risk stratification and guide decisions on extended endocrine therapy.

Meng-Yao Quan, Chang-Yan Wang, Hong Yuan et al. · 2 citations

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