Author

Cainian Huang

2 papers indexed here

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Open access Sep 2026

PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.

Mitochondrial dysfunction is a potent trigger of inflammatory cell death; however, the precise signaling pathways linking mitochondrial damage to pyroptosis remain incompletely understood. Here, we identify a previously unrecognized pathway in which mitochondrial depolarization activates the PINK1-Parkin axis to drive...

Cheng-Hao Yan, Cai-Nian Huang, Xu Liu et al. · EMBO Reports · 0 citations

Jul 2026

The epigenetic KMT5C-HDAC1 axis promotes hepatocellular carcinoma stemness and progression through SERPINA4 repression and chromatin compaction

This work establishes the KMT5C-HDAC1 axis as a central epigenetic switch that governs HCC stemness and progression, revealing a co-targeting strategy for the treatment of aggressive HCC.

Hong-Bin Huang, Cainian Huang, Pangfei Yang et al. · Oncogene · 0 citations