Caio C. de Lima Silva

In Vivo Efficacy and Biochemical Target Engagement of a Chromene-Based Inhibitor of Trypanosoma cruzi Lysyl-tRNA Synthetase

Aminoacyl-tRNA synthetases (aaRSs) have emerged as essential and attractive antiparasitic targets. In Trypanosoma cruzi, in vivo evidence supporting lysyl-tRNA synthetase (LysRS) as a valid target has thus far been restricted to a single chemotype. Here, we report the repositioning of a chromene-based LysRS inhibitor d...