Open access
Jul 2026
Deletion of cytoplasmic β/γ-actin in the mouse heart protects from disease by augmenting sarcolemma stability
The actin cytoskeleton of the cardiomyocyte is organized into two structurally and functionally distinct filament networks. The sarcomeric thin filaments, built primarily from cardiac α-actin (αCA), generate contractile force, whereas a separate subsarcolemmal cytoplasmic network, built from β-actin (Actb gene) and γ-a...
Yasuhide Kuwabara, Caitlin Keezer, Eaman Abay et al.
· bioRxiv · 0 citations