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Author

Can Cao

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Open access Oct 2026

Structural insights into the ligand modulation of MRGPRX4 conformational plasticity

Chronic pruritus is a debilitating condition with limited treatment options, particularly in cholestatic liver diseases, where bile acid dysregulation is a known trigger. Although Mas-related G protein-coupled receptor X4 (MRGPRX4) has recently been identified as a key mediator of bile acid-induced pruritus, the struct...

Meng-Na Zhang, Yong-Xia Wang, Yun Huang et al. · 0 citations

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