Can Yu

Molecular Mechanisms of Targeted Therapy in Breast Cancer: An Integrated Signaling Network Perspective.

This work synthesizes current evidence on the signaling architecture underlying targeted therapy across breast cancer subtypes and proposes a four-layer network topology model of resistance integrating receptor tyrosine kinase reprogramming, epigenetic plasticity coupled with tumor microenvironment (TME) co-evolution, to avoid conflating preclinical observations with validated biomarkers.