Cao Yang

Nanozyme-integrated hydrogel orchestrates mitochondrial quality control to counter inflammatory and oxidative milieu during disc degeneration.

In vitro and in vivo evidence confirms that this dual-functional hydrogel attenuates NP cell inflammation and significantly retards the progression of IDD, offering a synergistic strategy that couples nanozyme-mediated antioxidant therapy with targeted FPR1 blockade, holding substantial promise for intervertebral disc repair.