Sep 2026
Electrostatic Regulation of Alpha-Synuclein Membrane Binding Couples Conformational Release to Aggregation Kinetics
These results identify a membrane charge density of 25–35% anionic lipid range as an electrostatic transition region in which the aggregation-prone NAC domain becomes solvent-exposed while the N-terminal anchor remains membrane-associated.
Mahdi Lavasani, Ping Lu, Shehani V. Siripala et al.
· Journal of the American Chem... · 0 citations