Open access
Aug 2026
HIV-1 promotes loss of CD4+ T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation
Vpr-mediated TCF7 depletion couples enhanced viral fitness to reprogramming of CD4+ T cell identity, generating permissive differentiated cells while impairing the maintenance of effective antiviral immunity via reduced T cell stemness.
Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres et al.
· bioRxiv · 0 citations