Drosophila and human transglutaminases are partially interchangeable, revealing evolutionary conserved roles in brain development
Transglutaminases (TGs) are a family of enzymes characterized by their calcium-dependent transamidation activity. In higher mammals, TG2 is the family member with the highest expression in the brain. Intriguingly, TG2 KO mice show no major neurodevelopmental abnormalities, which might be explained by compensation f...