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Author

Carmanah D. Hunter

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Open access Sep 2026

Human NEU3 and NEU4 enzymes prefer short polysialic acid substrates.

Regulation of sialic acids is important to many biological processes and involves both biosynthesis and catabolism. The human neuraminidase enzymes (hNEU) regulate many sialosides in human health and disease. Polysialic acid (polySia) is a polyanion of α(2 → 8) linked sialic acids with roles in nervous, reproductive, a...

Carmanah D. Hunter, Benjamin A. R. Bekkema, Christopher W. Cairo · 0 citations
Aug 2026

Genomic Instability in Systemic Sclerosis is Promoted by a PERK/FOXO1-Dependent Axis

This study highlights a novel mechanism whereby genotoxic signals in dcSSc promote cell survival via a PERK/FOXO1-dependent axis and associated metabolic remodeling and provides mechanistic insights related to how changes to the mutational landscape reduce pro-fibrotic signals in DF after ASCT.

Lamia Khan, Jun-Qin Wang, C. van Eeden et al. · 0 citations

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