The Molecular Landscape of the Senescence–EMT Interplay: Deciphering Tumour Plasticity Through Molecular Signatures and Multi-Omic Profiling
Therapy-induced senescence (TIS) is a common response to anticancer treatments, characterised by stable cell cycle arrest and the acquisition of a complex senescence-associated secretory phenotype (SASP). Initially regarded as a beneficial mechanism that limits tumour growth, growing evidence indicates that TIS is a hi...