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Author

Carolina R. Melo-Silva

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Open access Jul 2026

The roles of Type I interferon subtypes and signaling in mRNA lipid nanoparticle vaccine-induced CD8 T-cell protective immunity 2266569

It is demonstrated that the optimal induction of CD8 T-cells requires IFN-I signaling in multiple myeloid cell types, not just in CD8 T-cells, dendritic cells, or monocytes, and that regulation of IFN-β by NF-κB and all IFN-I subtypes by IRF is required to induce protective CD8 T-cells.

Samit Kafle, Brian Montoya, Carolina R. Melo-Silva et al. · 0 citations

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