ABSTRACT Autophagy is widely proposed to decline with age; however, direct evidence across human cell types remains limited. Moreover, it is unclear whether age‐associated changes in autophagy‐gene transcription are accompanied by corresponding changes in autophagic activity, and whether autophagic activity relates to...
Tatiana M. Moreno, Stephanie R. Heimler, Ryan J. Moran et al.· Aging Cell· 0 citations
Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.
Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini et al.· bioRxiv· 0 citations
How genetic and pharmacologic perturbations of actin structure and function influence lifespan and various hallmarks of aging in Caenorhabditis elegans is interrogated, providing a comprehensive and publicly accessible resource that maps, for the first time, how changes in actin integrity correlate with diverse aging p...
Maxim Averbukh, Hunter T. Nelson, Tiffany Wang et al.· iScience· 2 citations
It is shown that the sulfotransferase CHST7 stabilizes fibroblast fate via CD44/JUNB signalling, and that its inhibition enhances cardiac reprogramming and improves heart repair, and defines a sulfotransferase-dependent barrier to cell fate conversion with therapeutic implications for heart regeneration.
Michaela R. Romero, S. Murphy, Yu-Zhu Chang et al.· Nature Communications· 0 citations
It is shown that the neuronal expression of the chromatin reader BET-1 promotes longevity and resilience in C. elegans through signaling mechanisms involving master transcription factors HSF-1 and DAF-16 and neurotransmitter UNC-13.
Naibedya Dutta, Daniel Hicks, Edgar Esparza et al.· Genes & Development· 0 citations
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