Open access
Aug 2026
Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity
Mechanistic understanding of inter-subunit communication in PRMT1 oligomers is expanded and half-of-sites reactivity is identified as a previously unrecognized regulatory feature that may be leveraged for the development of PRMT1-selective allosteric inhibitors.
Vincent Rossi, Robert S. Wilson-Kovacs, Yuan Gao et al.
· Journal of Biological Chemis... · 0 citations