Open access
Aug 2026
Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.
Overexpression of CHCHD2 in METTL5-KO NPCs rescued proliferation and partially rescued oxidative metabolism in NPCs and ventricle formation in organoids, highlighting a previously uncharacterized connection between CHCHD2, oxidative metabolism, and METTL5-mediated regulation of human neurogenesis.
Elena M Turkalj, Gugene Kang, I. Liu et al.
· Stem Cell Reports · 0 citations