Author

Carolyn L. Cummins

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Open access Sep 2026

The nematode Caenorhabditis elegans has a cationic amphiphilic drug (CAD) defense system

Cationic Amphiphilic Drugs (CADs) severely disrupt lysosomal function, which leads to a cellular pathology in humans characterized by excess phospholipids called phospholipidosis. Through a forward genetic screen and mining of published datasets, we discovered that CADs induce the expression of the CYP-35B family of cy...

Levon Tokmakjian, Duhyun Han, Kateryna Sihuta et al. · PLoS Biology · 0 citations

Open access Sep 2026

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

Non-coding RNAs from the Dlk1-Dio3 locus are critical for the maturation of metabolic tissues in early stages of postnatal development; however, their role in the mature organs remains elusive. Herein, we show that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in livers of subjects with obesity an...

Manuel Gil-Lozano, E. Simoes, Mo-Ya Wu et al. · Nature Communications · 0 citations