Carolyn S. P. Lam

Efficacy of Vericiguat by Background Guideline-Directed Medical Therapy in the VICTOR Trial.

BACKGROUND AND AIMS It is uncertain whether the effect of vericiguat varies across levels of background guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF). METHODS We conducted an exploratory analysis of VICTOR, which enrolled 6105 ambulatory patients with HFrEF without...

HFpEF in Asia Distinct Phenotypes, Shared Mechanisms, and Emerging Insights

HFpEF in Asia: Distinct Phenotypes, Shared Mechanisms, and Emerging Insights.

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous, comorbidity-driven syndrome of increasing global prevalence, with Asian patients displaying a distinctive and clinically relevant epidemiologic and biological profile. Compared with Western cohorts, Asian patients are often younger and less over...