Author

Cassandra S. Markham

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Sep 2026

Abstract B059: Loss of Cullin-RING Ligase 5 mediates resistance to RAS inhibition in pancreatic cancer

How selective modulation of protein degradation governs adaptive resistance to RAS inhibition governs adaptive resistance to RAS inhibition and provide a framework for developing rational combination strategies to improve the durability of RAS-targeted therapies in PDAC is defined.

Cassandra S. Markham, Ilze M. Olivi Gomes, Yi Di et al. · Cancer Research · 0 citations

Open access Sep 2026

Baseline cellular state shapes the molecular impact of mutant Kirsten rat sarcoma viral oncogene homologue (KRAS) alleles in reconstituted pancreatic cancer cells

This study establishes a comprehensive multi-omics resource for KRAS signalling in PDAC and demonstrates that cellular context exerts a stronger influence than allele identity in shaping molecular profiles, with implications for interpreting putative allele-specific signalling dependencies.

Yanixa Quiñones-Avilés, Barbora Šalovská, Cassandra S. Markham et al. · Molecular Omics · 0 citations