Open access
Oct 2026
Ryanodine receptor cluster remodeling links COL4A2 mutation to cerebral artery dysfunction
Pathogenic variants of COL4A1 and COL4A2, which encode the α1 and α2 chains of type IV collagen in vascular basement membranes, cause cerebral small vessel disease and intracerebral hemorrhage, but the signaling mechanisms that precede vascular damage remain incompletely defined. Here, we investigated cerebral arterial...
Boris Lavanderos, Evan Yamasaki, Alfredo Sanchez-Solano et al.
· bioRxiv · 0 citations