Author

Catherine J. Betts

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Review Open access Sep 2026

Immunocytokines in cancer: a safety perspective

Immunocytokines (ICs) are engineered biologics comprising a fusion of cytokines to antibodies, designed to deliver targeted cytokines to diseased tissues and mitigate the severe safety challenges associated with systemic cytokine therapy. A rapidly growing number of clinical trials have evaluated ICs, largely based on...

Kushal Prajapati, Catherine J. Betts, Richard Stebbings · Frontiers in Immunology · 0 citations

Open access Sep 2026

Beyond natural amino acids: extending immunogenicity risk assessment to modified peptides through chemical feature encoding. A case study on citrullination

Introduction Peptide therapeutics are increasingly explored to treat challenging diseases, but immunogenicity risks limit their clinical success. In silico tools enable immunogenicity screening through prediction of peptide-MHCII binding, yet current methods do not account for chemical properties of non-natural amino a...

M. Cairoli, Morten Nielsen, Catherine J. Betts et al. · Frontiers in Immunology · 0 citations