Cathy Yang

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis

Hundreds of mutations to the broadly expressed LMNA gene cause disease primarily within cardiac, muscular, and adipose tissues1. Tissue-specific pathogenesis arises when mutant protein dysfunction collides with the unique demands of a specific cell type. Here, we decipher the cell-type-specific consequences of ∼15,000...