Cátia Rebelo de Almeida

CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal Cancer

Checkpoint immunotherapy has transformed cancer treatment, yet current approaches targeting adaptive immunity benefit only a subset of patients, leaving innate immunity as a largely untapped therapeutic frontier. Here, we identify CD24 as an innate immune checkpoint that protects colorectal tumors from macrophage-media...