Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno‐Free Culture Systems
The skin provides a model for regenerative medicine, prompting the design of cultured reconstructed tissue substitutes. Translational research and bioengineering have indeed given rise to clinical applications such as the grafting of cultured skin substitutes in severe burn patients, more than four decades ago, and mor...