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Although BC200 was co-opted approximately 40 million years ago to regulate neuronal translation, it is shown that it never lost its mobilization capacity and functioned as a "master" source of L1-mediated germline retrotransposition events throughout anthropoid evolution, spawning hundreds of lineage-specific insertion...
These results identify POGZ as a G9a/GLP-associated chromatin regulator that protects neurodevelopmental gene domains from heterochromatinization and perinuclear sequestering, preserving 3D architecture and transcription during cortical development.
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