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Author

Celine Cuche

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Open access Aug 2026

Capsid stabilization reprograms the nuclear fate of the HIV genome

Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)—a first-in-class capsid inhibitor—impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import. In LEN-treated cells, ultrastructural analyses reveal preserved conical capsids persisting within nucl...

Thierry Mourer, M. Harastani, Celine Cuche et al. · 0 citations

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