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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Celine Eidenschenk

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Open access Sep 2026

A scalable human neuron model of Alzheimer’s disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction

The development of scalable iPSC-neuron models enables tauopathy drug discovery and reconstructs progressive Tau seeding, fibrillization and synaptic dysfunction, and establishes a physiologically relevant, scalable platform for therapeutic screening that connects Tau seed uptake, site-specific phosphorylation, fibril...

J. Lipka, Xiwei Shan, Qiao Zhang et al. · 0 citations
Open access Aug 2026

A massively parallel CRISPR-based screening platform for modifiers of neuronal depolarization

A platform to uncover genes affecting neuronal excitability in scalable CRISPR screens using CRISPRi and the fluorescent calcium integrator CaMPARI2 is developed to uncover molecular mechanisms controlling neuronal function in health and disease.

Steven C. Boggess, Vaidehi Gandhi, Ming-Chi Tsai et al. · 0 citations

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