Author

Celso de Oliveira Rezende

3 papers indexed here

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Open access Aug 2026

Piperazine and Morpholine Protoporphyrin IX Derivatives Intensify Biomolecules Oxidation and Phototoxicity in Triple‐Negative Breast Cancer

Photodynamic therapy (PDT) is a clinically established approach that relies on the localized generation of reactive oxygen species (ROS) mediated by a photosensitizer (PS), light, and molecular oxygen. Protoporphyrin IX (PpIX) is an approved PS; however, its intracellular retention is limited, factor that can alter its...

Maynne Duarte Suriani Franco, Thibault Joseph William Jacques Dit Lapierre, Tarcísio Paiva Mendonça et al. · ChemMedChem · 0 citations

Open access Sep 2026

Effects of Mono‐ and Dicapsaicinoid Functionalization on the Physicochemical Properties and Antimicrobial Photodynamic Activity of Protoporphyrin IX

Antimicrobial photodynamic therapy (aPDT) is a promising alternative for combating multidrug‐resistant bacteria and overcoming limitations of conventional antimicrobial treatments. To improve aPDT performance, two Protoporphyrin IX (PpIX) derivatives functionalized with one or two capsaicin fragments were synthesized a...

I. V. da Cunha, G. G. Calefi, N. B. S. Silva et al. · ChemMedChem · 0 citations

Open access Aug 2026

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

In vitro investigation of Benzenesulfonylpiperazines 2 revealed that it exerts a cytostatic effect on Leishmania infantum promastigotes, promoting cell cycle arrest during the G0/G1 phase which may potentially be linked to the production of reactive oxygen species.

Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos et al. · Chemical Biology and Drug De... · 0 citations