Cem Uguz

Prioritizing Candidate YB‑1 Cold Shock Domain Ligands via 5D-ElectroShape and Boltz Generative Cofolding

Y-box binding protein 1 (YB-1) acts as a key oncoprotein, with its highly conserved cold shock domain (CSD) driving core nucleic acid-binding functions in cancer progression. Despite its therapeutic relevance, the CSD is considered “undruggable” due to the lack of a well-defined hydrophobic pocket. To overcome the limi...