Author

Cen-Cen Lei

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Aug 2026

Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.

LW-1 represents a promising CDK8 inhibitor with improved drug-like properties and potent anti-psoriatic efficacy, providing a potential therapeutic candidate for the treatment of psoriasis and other inflammatory diseases.

Cen-Cen Lei, Dawei Jin, A-Jun Liu et al. · Bioorganic chemistry (Print) · 0 citations