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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Chagaleti Bharath Kumar

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3 papers indexed here

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Oct 2026

Machine learning-guided discovery of a novel natural CDK7 inhibitor for triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted therapeutic options; while sacituzumab govitecan and PARP inhibitors (for BRCA-mutated TNBC) have received regulatory approval in specific patient subgroups, the majority of TNBC patients continue to lack effective targete...

Chagaleti Bharath Kumar, Gandi Sony Pears · 0 citations
Aug 2026

Synthesis and in silico evaluation of novel hybrid 1,4-benzothiazine-1,1-dioxide-bis(1,2,3-triazole) derivatives as potential SRC kinase inhibitors via 1,3-dipolar cycloaddition.

Herein, we report the synthesis of new 1,4-benzothiazine-1,1-dioxide derivatives bearing bis(1,2,3-triazole) moieties via click chemistry in good to high yields and fully characterized by 1H NMR, 13C NMR and HRMS. The compounds were evaluated using a combined in silico approach, including physicochemical, pharmacokinet...

Ezaddine Irrou, Chagaleti Bharath Kumar, Y. Riadi et al. · 0 citations
Aug 2026

One-Pot Synthesis of Naphthalen-2-Thiazolidinones as Potential Breast Cancer Therapeutics: An Integrative Approach Using Network Pharmacology, Biomolecular Simulations and in Vitro Evaluation

Overall, the moderate promising leads of NT1 and NT9 emerged with dual-target potential for breast cancer, supporting further optimization and preclinical assessment.

C. N. Babu, Mazin Aboobaida Abdalla Abdelaziz, N. Nizamuddin et al. · 0 citations

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