In vitro and in silico antiviral activity of Polyscias scutellaria leaf extract against drug-susceptible and drug-resistant herpes simplex virus and human papillomavirus-positive cervical cancer: implications for topical formulation development
Highlights • Polyscias scutellaria leaf extract significantly inhibited drug-resistant HSV-1, and HPV-16 pseudovirus infections.• P. scutellaria fresh leaf ethanolic extract significantly downregulated HPV-16 E6, BCL2 and NFKB1, while upregulating BAX mRNA expression.• Most of the 20 metabolites with the highest relati...