Author

Chan Yang

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Open access Sep 2026

A novel ursodeoxycholic acid derivative exhibits broad-spectrum antiviral activity against influenza A virus and coronaviruses by multiphasic disruption of the viral life cycle

ABSTRACT Seasonal influenza virus and human coronaviruses (HCoVs) represent persistent threats to global public health, with current antiviral agents limited by narrow-spectrum activity and the emergence of drug resistance. Multi-stage and multi-target antiviral agents enhance therapeutic efficacy and overcome drug res...

Zheng Peng, Hao-Xing Yuan, Jun-Ran Huang et al. · Antimicrobial Agents and Che... · 0 citations

Open access Oct 2026

GTPase GBP7 promotes HSV-1 infection by interacting with and activating eEF1A1 to accelerate the protein translation process.

Guanylate-binding proteins (GBPs) are immune GTPases induced by interferons (IFNs) and comprise GBPs1-7. In this study, GBP7, a less studied member of the GBPs, was identified to possess Herpes simplex virus I (HSV-1) promoting effects on replication both in vitro and in vivo. Knockdown of GBP7 or loss of its GTPase ac...

Jin-Shen Wang, Liang-Bing Man, Bin-Hao Rong et al. · PLoS Pathogens · 0 citations