Aug 2026
4-Octyl itaconate attenuates cerebral ischemia reperfusion injury by mitigating mitochondrial dysfunction mediated neuronal apoptosis and ferroptosis via the Nrf2/HO-1/SLC7A11/GPX4 axis.
It is suggested that 4-OI confers Neuroprotection against I/R injury by activating Nrf2 pathway, reducing oxidative stress, and suppressing ferroptotic and apoptotic cell death.
Chandan Chauhan, Ravinder K. Kaundal
· Mitochondrion (Amsterdam. Pr... · 0 citations