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Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy
ABSTRACT Despite advancements in immune checkpoint blockade (ICB) therapy, breast cancer shows limited response to anti‐PD1/PD‐L1 treatments, emphasizing the need for alternative ICB targets. Here, we reveal that endocrine therapeutics, specifically tamoxifen, create an immunosuppressive yet primed tumor microenvironme...
Depletion of CARM1 slows in vivo tumorigenicity and rewires developmental programming in glioma stem-like cells
Findings identify CARM1 as a regulator of GSC developmental programs and NGFR/NTRK-dependent survival and a role for CARM1-dependent NFIA methylation in NGFR repression in NGFR repression.