Open access
Aug 2026
A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity
Membrane recruitment is a fundamental regulator of protein function. However, the allosteric mechanisms by which lipid binding controls protein activity remain poorly understood. In autophagy, the ubiquitin-like protein LC3 is lipid-anchored to autophagosomes, where it is essential for receptor recruitment and vesicle...
Deepanshi Gahlot, Jesu Castin, S. Mathur et al.
· Nature Communications · 0 citations