Author

Chang-An Geng

3 papers indexed here

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Sep 2026

Deoxycalyxin A exerts hypoglycemic effects through activating TGR5-induced GLP-1 secretion via TGR5/PKA/MEK/ERK pathway.

Type 2 diabetes mellitus (T2DM) is a heterogeneous metabolic disorder characterized by insulin resistance and progressive β cell dysfunction. Deoxycalyxin A (DCA), a unique diarylheptanoid-chalcone hybrid isolated from Alpinia katsumadai, was identified as a novel stimulator of GLP 1 secretion in both STC-1 (EC50: 10.7...

Sheng-Li Wu, Xiao-Feng He, Pianchou Gongpan et al. · Bioorganic chemistry (Print) · 0 citations

Sep 2026

Chemical constituents of Roscoea humeana: their anti-inflammatory and GLP-1 secretagogic activity.

Plants of the genus Roscoea have been widely utilized in traditional Chinese and Tibetan medicine for a variety of therapeutic purposes. However, the chemical constituents of Roscoea humeana remained unexplored to date. In this first phytochemical investigation of R. humeana, twelve compounds were isolated, including t...

Hang Fu, Xu Zhu, Sheng-Li Wu et al. · Fitoterapia · 0 citations

Aug 2026

Preparation and chemical characterization of polyphenol-rich extract from Tsaoko Fructus: alleviation of ulcerative colitis in mice by modulating gut microbiota and suppressing the JNK1-cJun signaling.

3CB significantly alleviated UC symptoms in DSS-induced mice, reshaped the gut microbiota with reducing pathogenic Pseudomonadota and Deferribacterota while enriching beneficial Bacteroidota, and restored microbial amino sugar and nucleotide sugar metabolism pathways of intestinal flora.

Pianchou Gongpan, Jing-yi Yang, Hang Fu et al. · Phytomedicine · 0 citations