Open access
Aug 2026
Novel Phosphodiesterase‑2 Inhibitors Discovered via Structure-Based Virtual Screening Targeting the Allosteric GAF‑B Domain.
It is demonstrated that incorporation of binding mode analysis into virtual screening workflows can substantially improve hit identification and may provide a valuable strategy for future virtual screening campaigns against PDE2 and other therapeutic targets.
Charles Adeniran, Gadam Myratgeldiyev, Fang Zheng et al.
· ACS Medicinal Chemistry Lett... · 0 citations