Author

Chang-Han Lee

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Open access Sep 2026

Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cells

Chimeric antigen receptor (CAR)-T cells and CAR-macrophages (or CAR-monocytes) offer complementary antitumor functions. CAR-T cells exert potent cytotoxicity against cancer cells, whereas CAR-macrophages can infiltrate solid tumors, phagocytose cancer cells and promote antigen spreading. Antibody-conjugated lipid nanop...

Ji-Su Hong, Jinwoong Lim, Minho Park et al. · bioRxiv · 0 citations

Open access Aug 2026

Focused framework sampling recovers binding-positive humanized anti-amyloid-β antibodies in a single sorting round

This workflow provides a practical route from immune-repertoire discovery to binding-positive humanized antibodies and applied the workflow to antibodies against amyloid-β (Aβ)-derived preparations.

Youngju Kim, Hayoung Kwon, Ji-Min Song et al. · bioRxiv · 0 citations

Jul 2026

KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer.

It is found that KRAS mutations remodel the N6-methyladenosine (m6A) epitranscriptome to promote immune evasion and highlight METTL3 as a promising therapeutic target.

Seungjae Shin, Seung-Pyo Hong, Seoho Lee et al. · Cancer Research · 0 citations