Chang-Hoon Woo

Therapeutic Implication of Anti-CTGF in Neointimal Hyperplasia via Regulating Mitochondrial Dysfunction and VSMC Phenotypic Switch.

Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein of the CCN family (CCN1-6) that regulates the proliferation of vascular smooth muscle cells (VSMCs), thereby contributing to the pathogenesis of atherosclerosis and hypertension. However, the intercellular signaling pathway that CTGF...