Review
Open access
Sep 2026
Mitochondrial Proteostasis Links Diabetes and Sarcopenia: Cross-Scale Convergence from Experimental Models to Human Multi-Omics
This review synthesizes evidence demonstrating how insulin resistance, hyperglycemia, lipotoxicity, and inflammation converge on skeletal muscle mitochondrial proteostasis to drive progressive decline in type 2 diabetes mellitus, and proposes a diabetes-centered framework where mitochondrial proteostasis failure mediat...
Shi-Bo Wei, Soyeon Shin, Dongryeol Ryu et al.
· Diabetes & Metabolism Journa... · 0 citations