Chang Shu

Gut microbiota-derived metabolites and host interactions in fibrotic diseases: mechanisms, cross-organ signatures, and therapeutic opportunities

Fibrosis is a common end-stage pathological change across multiple chronic organ injuries and a primary driver of global organ failure and high mortality. Accumulating evidence indicates that the gut microbiota and its metabolites can bidirectionally regulate fibrosis progression through the gut–organ axis; however, a...