Author

Chang-Wen Ye

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Oct 2026

A precursor-driven triterpenoid platform enables high-level biosynthesis of structurally distinct triterpenoids in Saccharomyces cerevisiae.

Sustainable microbial biomanufacturing of high-value triterpenoids in Saccharomyces cerevisiae is severely constrained by native sterol homeostasis, which rapidly channels the central intermediates 2,3-oxidosqualene (OSQ) and 2,3;22,23-dioxidosqualene (DOS) into essential ergosterol biosynthesis via lanosterol synthase...

Jing-Tao Zhou, Hai-Lang Ma, Chang-Wen Ye et al. · Bioresource Technology · 0 citations

Open access Aug 2026

Moldogenicity of dominant culturable molds in cigar tobacco leaves and GC-IMS–based analysis of volatile organic compounds

Introduction Cigar tobacco leaves (CTLs) are nutrient-rich and susceptible to mold contamination during fermentation and storage. This study aims to investigate the specific volatile profiles of dominant culturable molds recovered under the applied isolation conditions in CTLs and to establish a robust volatile organic...

Kuo Huang, Ge Zhang, Meng-Meng Liu et al. · Frontiers in Microbiology · 0 citations

Aug 2026

Mechanistic Decoupling of the cis - and trans -Cleavage Activities of Cas12a via Phosphorothioate-Induced Kinetic Trapping

It is demonstrated that the availability of the RuvC catalytic channel is determined not by induced fit binding but by the chemical cleavability of the occupant, which provides a theoretical framework and additional insights for developing more precise gene-editing tools and designing Cas12a-based in vitro diagnostic p...

Chenqi Niu, Yiyi Mi, Wanxia Zhao et al. · ACS Catalysis · 0 citations