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Author

Chang-Woo Lee

2 papers indexed here

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Aug 2026

Structural basis and preclinical efficacy of MG1124, a novel CEACAM1-targeting antibody synergizing with PD-1 blockade.

CEACAM1 homodimerization mediates tumor immune evasion, presenting a compelling target to overcome resistance to PD-1 blockade. However, defining a precise structural and pharmacological blueprint for CEACAM1 targeting has remained challenging. Here, we report the discovery and comprehensive preclinical characterizatio...

Jae-Chul Lee, Miyoung Oh, H. Nam et al. · 0 citations
Open access Jul 2026

Dual protein phosphatase promotes effector CD8+ T-cell persistence and tumor control 2241571

CD8+ T cell persistence is essential for long-term protection against cancer and infection. Immune checkpoint inhibitors improve cancer outcomes but still fail to sustain CD8+ T cell function under chronic antigen exposure. Kinases are well established in T cell-mediated tumor immunity, whereas protein phosphatas...

Min-Hee Kim, Chang-Woo Lee · 0 citations

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