Background: Polydatin has shown anti-inflammatory, antioxidant, and cytoprotective effects in preclinical studies. Its development is limited by low oral bioavailability, extensive metabolism, and poorly defined tissue exposure. Objectives: This review summarizes the pharmacology and delivery systems of polydatin, dist...
Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases, and its pathogenesis and treatment strategies remain major challenges. Recent advances in single-cell RNA sequencing and lineage tracing have revealed that vascular smooth muscle cells (VSMCs) are not merely passive structural components of...
Xin-Yue Wang, Meng-Na Zhang, Chu-Chuan Meng et al.· Ageing Research Reviews· 0 citations
INTRODUCTION
The combination of polydatin and hawthorn flavonoids (PH), a traditional Chinese medicine formulation for activating blood circulation and detoxification, has shown the potential to counteract atherosclerosis, but the mechanisms underlying its effects remain unclear.
PURPOSE
To investigate the protective...
Yu-Juan Li, Xiao-Nan Zhang, Sheng-Jie Yang et al.· Journal of Advanced Research· 1 citation
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